DISTEM

The recommended doses are:

Adults

The recommended dose is 2 tablets, from four to six times a day, depending on the severity of the symptoms. You should not take more than 12 tablets in 24 hours, and the interval between intakes will not be less than 4 hours.

Elderly patients

Elderly patients may need a lower dose to get the same pain and muscle spasms relief. The recommended dose is 1 tablet, 4 times a day.

Patients with kidney and liver problems

They may require a longer interval between intakes

POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If any of the following reactions occur, stop the treatment and notify your doctor immediately:

• Allergic reactions ranging from simple skin eruption or urticaria to more severe reactions such as anaphylactic reaction or angioedema (rash, itching, swelling of extremities, face, lips, mouth or throat that may cause you difficulty swallowing or breathing) or severe skin reactions.
• Jaundice (yellowing of skin and whites of the eyes), indicative of a liver problem.
• If you experience an infection with symptoms such as fever and pain call your doctor immediately, since it may be indicative of an alteration of white blood cells or platelets in blood, decreasing its resistance to infections.
• Convulsions or fainting (syncope).
  
  

The following adverse effect may occur rarely (may affect up to 1 in 1,000 people):

     – Headache, dizziness or light-headedness;

     – Conjunctivitis with nasal congestion;

     – Decrease in blood pressure, metallic taste, increase in hepatic transaminases;

     – Fever, malaise.

The following adverse effects may occur very rarely (may affect up to 1 in 10,000 people):

     – Nausea, vomiting;

    – Nervousness, anxiety, confusion, tremor, drowsiness, blurred vision, nystagmus (rapid and involuntary eye movements);

     – Low blood sugar levels, decrease in the frequency of heartbeat, reddening of the skin (flushing);

     –  Renal toxicity (dark urine);

     – Difficulty breathing.

The following adverse effects have been reported but the frequency cannot be estimated from available data:

     – Slight muscular incoordination, loss of memory, vertigo, insomnia, double vision;

     – Heartburn, dry mouth, fatigue, diarrhoea.